Publications

Selected publications

 

Manna M, Niemela M, Tynkkynen J, Javanainen M, Kulig W, Muller DJ, Rog T, and Vattulainen I. (2016)
Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol. 
eLife 5: e18432. DOI: http://dx.doi.org/10.7554/eLife.18432 [Full text]

Salo VT, Belevich I, Li S, Karhinen L, Vihinen H, Vigouroux C, Magré J, Thiele C, Hölttä-Vuori M, Jokitalo E, Ikonen E. (2016)
Seipin regulates ER-lipid droplet contacts and cargo delivery.
EMBO J. 35(24):2699-2716. [Full text]

Hyung JH, Javanainen M, Martinez-Seara H, Metzler R, and Vattulainen I. (2016)
Protein Crowding in Lipid Bilayers Gives Rise to Non-Gaussian Anomalous Lateral Diffusion of Phospholipids and Proteins.
Physical Review X 6, 021006 DOI: https://doi.org/10.1103/PhysRevX.6.021006
[Abstract]

Tojkander S, Gateva G, Husain A, Krishnan R, Lappalainen P.
Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly.(2015)
Elife. 4:e06126. doi: 10.7554/eLife.06126. [Abstract]

Blom T, Li S, Dichlberger A, Bäck N, Kim YA, Loizides-Mangold U,
Riezman H, Bittman R, and Ikonen E. (2015)
LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.
Nat Chem Biol. 11(10):799-806 [Abstract]

V. Sharma, G. Enkavi, I. Vattulainen, T. Rog, M. Wikstrom. (2015)
Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase.

PNAS USA 112: 2040 [Abstract]

Ghosh, R., de Campos, M. K. F., Huang, J., Huh, S. K., Orlowski, A., Yang, Y., Tripathi, A., Nile, A., Lee, H.-C., Dynowski, M., Schafer, H., Rog, T., Lete, M. G., Ahyayauch, H., Alonso, A., Vattulainen, I., Igumenova, T. I., Schaaf, G. and Bankaitis, V. A. (2015).
Sec14-nodulin proteins and the patterning of phosphoinositide landmarks for developmental control of membrane morphogenesis.
Mol Biol Cell. 26: 1764–1781 [Abstract]

Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstråle M, Minkeviciene R, Kuurne J, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus- Durner V, Hrabě de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera C, Hotulainen P (2015)
MIM-induced membrane bending promotes
dendritic spine initiation.

Dev Cell.33(6):644-59. [Abstract]

Kaszuba K, Grzybek M, Orłowski A, Danne R, Róg T, Simons K, Coskun Ü, Vattulainen I. (2015)
N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes.
PNAS 112, 4334-9

Äijänen T, Koivuniemi A, Javanainen M, Rissanen S, Rog T, Vattulainen I. (2014)
How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations.

PLoS Comput Biol. 10(11):e1003987. [Abstract]

Poukkula M, Hakala M, Pentinmikko N, Sweeney MO, Jansen S, Mattila J, Hietakangas V, Goode BL, Lappalainen P. (2014)
GMF promotes leading-edge dynamics and collective cell migration in vivo.
Curr Biol 24(21):2533-40. [Abstract]

Kremneva E, Makkonen MH, Skwarek-Maruszewska A, Gateva G, Michelot A, Dominguez R, Lappalainen P. (2014)
Cofilin-2 controls actin filament length in muscle sarcomeres.
Dev Cell. 31(2):215-26[Abstract]

Neuvonen M, Manna M, Mokkila S, Javanainen M, Rog T, Liu Z, Bittman R, Vattulainen I, Ikonen E. (2014)
Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes.
PLoS One 9(8):e103743. doi:10.1371/journal.pone.0103743. [Abstract]

Kanerva K, Uronen RL, Blom T, Li S, Bittman R, Lappalainen P, Peränen J, Raposo G, Ikonen E. (2013)
LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.
Dev Cell. 27(3):249-62. [Abstract]

Hölttä-Vuori M, Vainio S, Kauppi M, Van Eck M, Jokitalo E, Ikonen E. (2012)
Endosomal actin remodeling by coronin-1A controls lipoprotein uptake and degradation in macrophages.
Circ Res 110, 450-5. [Abstract]

Lingwood D, Binnington B, Róg T, Vattulainen I, Grzybek M, Coskun U, Lingwood CA, Simons K. (2011)
Cholesterol modulates glycolipid conformation and receptor activity.
Nature Chem Biol 7, 260-2. [Abstract]

Pykäläinen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela EV, Peränen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R, Lappalainen P. (2011)
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.
Nat Struct Mol Biol.18, 902-7. [Abstract]

Niemelä PS, Miettinen MS, Monticelli L, Hammaren H, Bjelkmar P, Murtola T, Lindahl E, Vattulainen I.(2010)
Membrane proteins diffuse as dynamic complexes with lipids.
J Am Chem Soc 132, 7574-5. [Abstract]

Saarikangas J, Zhao H, Pykäläinen A, Laurinmäki P, Mattila PK, Kinnunen PK, Butcher SJ, Lappalainen P. (2009)
Molecular mechanisms of membrane deformation by I-BAR domain proteins.
Curr Biol. Jan 27;19(2):95-107. [Abstract]

Mattila PK, Pykäläinen A, Saarikangas J, Paavilainen VO, Vihinen H, Jokitalo E, Lappalainen P. (2007)
Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism.
J Cell Biol 176, 953-64. [Abstract]